Figure xA The measured dose response curve of the control

Bergeron et al. [15] reported that the clinical duration (time to 25% twitch recovery) of the 0.15 mg kg−1 dose of cisatracurium was 59 min. This figure was comparable to the 55 min image reported by Bluestein et al. [16] at the same dose and under similar anesthetic conditions.
From continuous infusions of atracurium used during liver transplantation, it Talampanel appeared that the rate of atracurium infusion required during liver transplantation was not different from that in patients with normal hepatic function [17]. Conversely, Cammu et al. [18] reported that cisatracurium dose requirements during liver transplantation tended to be higher than reported infusion rates of cisatracurium in healthy subjects (1.4 ?g kg−1 min−1).
In most pharmakokinetic–pharmakodynamic studies for cisatracurium, isoflurane was used as the anesthetic agent. During these conditions, administration of a 0.1 mg kg−1 bolus dose of cisatracurium resulted in a mean EC50 value of 98 ng ml−113 and 19. This low EC50 value is in agreement with the known potentiating effect of isoflurane. When propofol was used as the anesthetic agent the mean EC50 value derived after a 5-min infusion of a 0.1-mg kg−1 dose of cisatracurium was 153 ng ml−115 and 20.
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