In conclusion, elevated MMP-3 serum levels reflect disease activity in RA patients and can be used as a specific marker for joint damage but the cross sectional design of this Pepstatin A study
did not allow us to produce conclusions with respect to disease course and prognosis. Thus we recommend further studies on large numbers of patients and serial measurements
of MMP-3 to determine the rate of disease progression or erosion development and we recommend using MMP-3 level as a useful marker for disease activity.
Conflicts of interest
The authors declare no conflicts of interest.
CD14++CD16+ monocytes; CD14+CD16+ monocytes; IL17; Rheumatoid arthritis; Disease activity score (DAS28)
Accumulating evidence supports that cluster of differentiation CD4+CD25+ regulatory T cells
play an essential role in controlling rheumatoid arthritis (RA) . T helper-17 cells and interleukin (IL-17) play an important role in the pathogenesis of inflammatory and destructive pattern characteristic . In a previous study, proteinase-activated receptor-2 expression on monocytes was remarkably high in active RA patients and consistent with a pathogenic role while its expression on CD3+ T-cells was not .